Genos Glyco

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PICTURE.

About us

Glycans are complex oligosaccharides covalently attached to the backbone of proteins. They significantly contribute to the structure and function of the majority of proteins. Changes in glycans have been reported in many inflammatory diseases, autoimmune diseases and in cancer where they reflect disease activity, or in some cases even precede the development of disease.

Global leader in glycomics

The field of high-throughput glycomics was opened with our 2008 study of total plasma glycome on over 1,000 individuals from the Croatian island Vis. Today we have over 10 years of experience in glycomics, over 100 research publications and more than 30 scientists completely devoted to answering opened questions about glycans and their functional roles in biology.

Research

The knowledge about glycans is lagging significantly behind the knowledge about DNA and proteins and through multiple bilateral and multilateral research projects, including the Human Glycome Project, we are trying to narrow this gap. We are proud to be able to collaborate with leading scientists and contribute glycan data to some of the best clinical and epidemiological cohorts in the World (including TwinsUK, 10001 Dalmatians, ORCADES, EPIC, KORA, Finrisk, SABRE, etc)

Commercial services

Our knowledge and expertise is available to any interested party in academia or industry through high-throughput glycan analysis and other commercial services that we offer, ranging from analytical chemistry to study design and statistical data analysis.

Featured publications

Year Title Reference Authors
2019 Plasma Fucosylated Glycans and C-Reactive Protein as Biomarkers of HNF1A-MODY in Young Adult–Onset Nonautoimmune Diabetes Diabetes Care 42 (1):17-26. Juszczak A, Pavić T, Vučković F, Bennett AJ, Shah N, Pape Medvidović E, Groves CJ, Šekerija M, Chandler K, Burrows C, Rojnić Putarek N, Vučić Lovrenčić M, Ćuća Knežević J, James TJ, Gloyn AL, Lauc G, McCarthy MI, Owen KR and Gornik O
2018 Protein N-Glycosylation in Cardiovascular Diseases and Related Risk Factors Curr Cardiovasc Risk Rep (2018) 12: 16. https://doi.org/10.1007/s12170-018-0579-4 Gudelj I and Lauc G
2018 Definition and genetic control of the murine immunoglobulin G glycome Nature Chem Biol 14:516–524, doi:10.1038/s41589-018-0034-3 (IF=15.066; rank 5/290 Biochemistry & Mol Biol) Krištić J, Zaitseva O, Ram R, Nguyen Q, Novokmet M, Vučković F, Vilaj M, Trbojević-Akmačić I, Pezer M, Davern KM Morahan G, Lauc G
2018 MIgGGly (mouse IgG glycosylation analysis) – a high-throughput method for studying Fc-linked IgG N-glycosylation in mice with nanoUPLC-ESI-MS Scientific Reports 8:13688 doi:10.1038/s41598-018-31844-1 (IF= 4.259; Rank 10/64 – Multidisciplinary Science) Zaytseva OO, Jansen BC, Hanić M, Mrčela M, Razdorov G, Stojković R, Erhardt J, Brizić I, Jonjić S, Pezer M and Lauc G
2018 Promoter methylation of the MGAT3 and BACH2 genes correlates with the composition of the immunoglobulin G glycome in inflammatory bowel disease Clinical Epigenetics, 10:75 doi: 10.1186 (IF = 6.091; Rank: 36/222 Oncology) Klasić M, Markulin D, Vojta A, Samaržija I, Biruš I, Dobrinić P, Ventham NT, Trbojević-Akmačić I, Šimurina M, Štambuk J, Razdorov G, Kennedy NA, Satsangi J, Dias AM, Pinho S, Annese V, Latiano A, D'Inca R, IBD consortium Lauc G and Zoldoš V

Services

  • High-throughput analyses
  • In depth glycoprofiling
  • Study design
  • Data analysis
  • Joint project development

Our team

Dr. Gordan Lauc

Founder and CEO

Dr. Maja Pučić Baković

Head of Glycoprofiling

Dr. Mislav Novokmet

Head of MS Laboratory

Dr. Irena Trbojević Akmačić

Head of UPLC Laboratory

Dr. Frano Vučković

Head of Data Analysis

Dr. Marina Martinić Kavur

Head of Coorporate Communications

Dr. Marija Pezer

Dr. Ivan Gudelj

Dr. Jasminka Krištić

Dr. Andrea Skelin

Dr. Olga Zaitseva

Dr. Jerko Štambuk

Ana Cindrić

Helena Deriš

Siniša Habazin

Maja Hanić

Filip Kliček

Julija Jurić

Elham Memarian

Anne-Marie Patenaude

Tea Petrović

MSc. Genadij Razdorov

Thomas Senard

Jelena Šimunović

Mattia Vacchini

Iwona Wojcik

Ivana Kolić

Maja Glazer

Dijana Peić